DL-Lysine Acetylsalicylate

DL-Lysine Acetylsalicylate is a part of the non-steroidal anti-inflammatory drugs (NSAIDs) group, it may inhibit cancer cell line growth. It is water-soluble and, the compound is an analgesic, antipyretic and anti-inflammatory. Acetylsalicylates with basic amino acids such as DL-lysine is stabilized in the form of solid preparation.

Because of its limited solubility in water, aspirin has been prescribed as an oral drug. When orally administered, however, it is hydrolyzed by the strongly acidic gastric juice, forming salicylic acid which irritates the gastric mucosa. To avoid this, an attempt has been made to improve the method for administrating acetylsalicylic acid and succeeded in preparing a salt easily soluble in water by reacting acetylsalicylic acid and a basic amino acid. Because of its instability in an aqueous medium, the acetylsalicylate of basic amino acid must be in the form of powder in order to insure stability until the time when it is used.

Technical Information

CAS Number:

62952-06-1

Molecular Weight:

326.34

Molecular Formula:

C15H22N2O6

Physical State:

Solid

Solubility:

Soluble in Water

Storage:

Store at -20° C

Melting Point:

140-142°C (lit.)

Applications
  • Non-steroidal anti-inflammatory drugs (NSAIDs) may inhibit cancer growth
  • Water soluble, injectable aspirin derivative
  • Analgesic; antipyretic; anti-inflammatory
  • Acetylsalicylic acid (aspirin) has long been used as an analgesic, antipyretic and anti-rheumatic, more recently, it is widely used as a non-steroid anti-inflammatory in treating arthritis, neuralgia and myalgia
References
  • Korttila, K, et alBr. J. Anaesth. 1980;52:613.
  • Diaz C, et al. Clin Ther. 1981;4:121.
  • Wolff F, et alArch Gynecol. 1982;233:15.
  • Bretagne JF, et alGastroenterol Clin Biol. 1984;8:28.
  • H. von Ross, et al. Klin Wochenschr. 1978;56:1119.
  • Gentit F. Gaz Med Fr. 1979;86:4539.
  • Richez P, et al. J Vet Pharmacol Ther. 1979;2;231.
  • Eidem. ibid. 1980;3:121.

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