Bioplus Fine Chemistry

Small Molecules

Bioplus's small molecule team designs the synthesis of complex organic molecules using reported or novel reaction schemes. We have the expertise to handle alkyl lithiums, air and moisture sensitive reagents, reactions under inert conditions, metal mediated reactions, etc. Access to various databases like Scifinder and Beilstein Crossfire help us to plan the reaction schemes, while the Available Chemicals Directory (ACD) enables us to identify the source of the starting materials. We use state-of-the-art analytical facilities to identify prepared compounds and elucidate the structure of synthesised molecules in order to ascertain their purity.

Scale Up

Bioplus's scale up team has particular competence in providing custom-synthesised building blocks for the construction of combinatorial libraries. We have acquired technical capabilities in scaling up complex chemical and biochemical processes. Our cGMP accredited pilot plant (glass-lined and stainless steel chemical reactors: 20 liters -1500 liters) is fully equipped to develop intermediates and final products.

Custom Synthesis

Bioplus's custom synthesis unit supplies novel customised molecules at a kilogram scale. Novel process development for API's, intermediate synthesis, synthesis of standard impurities and reference compounds are also routinely carried out at this unit.
Synthesis of organic molecules involves diverse chemistry. Some of the reactions carried out by our custom synthesis unit at gram to kilogram scale include:

• Hydrogenation
• Oxidation
  
• Reduction
  
• Reactions using LDA
  
• Chlorination
  
• Sulfonation
  
• Nitration
  
• Metal-mediated synthesis

In addition, we conduct reactions under low temperature, and inert conditions. We have considerable experience in multi-step synthesis.